{"id":1563,"date":"2023-01-01T10:20:44","date_gmt":"2023-01-01T15:20:44","guid":{"rendered":"https:\/\/calliope.health\/?page_id=1563"},"modified":"2024-05-01T14:06:41","modified_gmt":"2024-05-01T18:06:41","slug":"spravato-vs-ketamine","status":"publish","type":"page","link":"https:\/\/calliope.health\/spravato-vs-ketamine\/","title":{"rendered":"Esketamine (Spravato) vs. Ketamine: What you Need to Know"},"content":{"rendered":"<style>.kb-row-layout-id1563_7763ec-20 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1563_7763ec-20 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1563_7763ec-20 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 2fr) minmax(0, 1fr);}.kb-row-layout-id1563_7763ec-20 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1563_7763ec-20 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1563_7763ec-20 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1563_7763ec-20 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-left-golden kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1563_95c09b-dc > .kt-inside-inner-col,.kadence-column1563_95c09b-dc > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1563_95c09b-dc > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1563_95c09b-dc > .kt-inside-inner-col{flex-direction:column;}.kadence-column1563_95c09b-dc > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1563_95c09b-dc > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1563_95c09b-dc{position:relative;}@media all and (max-width: 1024px){.kadence-column1563_95c09b-dc > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column1563_95c09b-dc > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1563_95c09b-dc inner-column-1\"><div class=\"kt-inside-inner-col\">\n<p>Ketamine and esketamine\/Spravato are both medications that belong to a class of drugs called dissociative anesthetics. They are both used for similar purposes, such as sedation, pain management, as an anesthetic, and in psychiatry to treat depression and its related behavioral complications.<\/p>\n\n\n\n<p>However, there are some differences between the two drugs. Ketamine is the more well-known and commonly used of the two, and it is available in oral, intravenous, and intramuscular forms. It is also used off-label as a rapid antidepressant in treatment-resistant depression and other mood disorders.<\/p>\n\n\n\n<p>Esketamine was approved by the FDA in 2019 for treatment-resistant depression. Esketamine is the S-enantiomer of ketamine, which means it is one of the two mirror-image forms of the ketamine molecule. It is a nasal spray and is only approved for use in treatment-resistant depression. A person using esketamine for treatment must also be taking another oral antidepressant medication concurrently.<\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column1563_6f0463-c6 > .kt-inside-inner-col,.kadence-column1563_6f0463-c6 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1563_6f0463-c6 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1563_6f0463-c6 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1563_6f0463-c6 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1563_6f0463-c6 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1563_6f0463-c6{position:relative;}@media all and (max-width: 1024px){.kadence-column1563_6f0463-c6 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column1563_6f0463-c6 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1563_6f0463-c6 inner-column-2\"><div class=\"kt-inside-inner-col\">\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"678\" src=\"https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_236741859-1024x678.jpeg\" alt=\"\" class=\"wp-image-1564\" srcset=\"https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_236741859-1024x678.jpeg 1024w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_236741859-300x199.jpeg 300w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_236741859-768x509.jpeg 768w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_236741859-1536x1017.jpeg 1536w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_236741859-2048x1356.jpeg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div><\/div>\n\n<\/div><\/div>\n\n<style>.wp-block-kadence-advancedbtn.kb-btns1563_973d50-48{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns1563_973d50-48 .kt-button{font-weight:normal;font-style:normal;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns1563_973d50-48\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn1563_16ba11-44.kb-button{width:initial;}.wp-block-kadence-advancedbtn .kb-btn1563_16ba11-44.kb-button{color:#555555;border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}.wp-block-kadence-advancedbtn .kb-btn1563_16ba11-44.kb-button:hover{color:#ffffff;background:#444444;border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}@media all and (max-width: 1024px){.wp-block-kadence-advancedbtn .kb-btn1563_16ba11-44.kb-button{border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}}@media all and (max-width: 1024px){.wp-block-kadence-advancedbtn .kb-btn1563_16ba11-44.kb-button:hover{border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}}@media all and (max-width: 1024px){.kb-btn1563_16ba11-44.kb-button .kb-svg-icon-wrap{display:block;}}@media all and (max-width: 767px){.wp-block-kadence-advancedbtn .kb-btn1563_16ba11-44.kb-button{border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}.wp-block-kadence-advancedbtn .kb-btn1563_16ba11-44.kb-button:hover{border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}}<\/style><a class=\"kb-button kt-button button kb-btn1563_16ba11-44 kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-outline kt-btn-has-text-true kt-btn-has-svg-false wp-block-kadence-singlebtn\" href=\"https:\/\/calliope.health\/contact\/\"><span class=\"kt-btn-inner-text\"><strong>START YOUR HEALING JOURNEY<\/strong><\/span><\/a><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_277237134-1024x683.jpeg\" alt=\"Esketamine (Spravato) vs. Ketamine\" class=\"wp-image-1565\" srcset=\"https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_277237134-1024x683.jpeg 1024w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_277237134-300x200.jpeg 300w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_277237134-768x512.jpeg 768w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_277237134-1536x1024.jpeg 1536w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_277237134-2048x1365.jpeg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n<style>.kb-row-layout-id1563_f8bb49-ee > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1563_f8bb49-ee > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1563_f8bb49-ee > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 1fr) minmax(0, 2fr);}.kb-row-layout-id1563_f8bb49-ee > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1563_f8bb49-ee > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1563_f8bb49-ee > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1563_f8bb49-ee alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-right-golden kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1563_abfad4-63 > .kt-inside-inner-col,.kadence-column1563_abfad4-63 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1563_abfad4-63 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1563_abfad4-63 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1563_abfad4-63 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1563_abfad4-63 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1563_abfad4-63{position:relative;}@media all and (max-width: 1024px){.kadence-column1563_abfad4-63 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column1563_abfad4-63 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1563_abfad4-63 inner-column-1\"><div class=\"kt-inside-inner-col\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"788\" src=\"https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_492435334-1024x788.jpeg\" alt=\"\" class=\"wp-image-1566\" srcset=\"https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_492435334-1024x788.jpeg 1024w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_492435334-300x231.jpeg 300w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_492435334-768x591.jpeg 768w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_492435334-1536x1182.jpeg 1536w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_492435334-2048x1575.jpeg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Esketamine molecule. It is the S-enantiomer of ketamine, with analgesic, anesthetic and antidepressant activities<\/figcaption><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column1563_79a228-bb > .kt-inside-inner-col,.kadence-column1563_79a228-bb > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1563_79a228-bb > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1563_79a228-bb > .kt-inside-inner-col{flex-direction:column;}.kadence-column1563_79a228-bb > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1563_79a228-bb > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1563_79a228-bb{position:relative;}@media all and (max-width: 1024px){.kadence-column1563_79a228-bb > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column1563_79a228-bb > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1563_79a228-bb inner-column-2\"><div class=\"kt-inside-inner-col\">\n<p><strong>A quick detour into basic chemistry<\/strong>&nbsp;<\/p>\n\n\n\n<p>We often hear the term \u201cracemic ketamine.\u201d What does this mean?&nbsp;<br><br>Ketamine is a racemic mix of two enantiomers: esketamine and arketamine. In other words, esketamine is one enantiomer of racemic (generic) ketamine.<\/p>\n\n\n\n<p>A racemic molecule, also known as a racemate, is a mixture of equal amounts of two mirror-image forms of a compound, known as enantiomers. Enantiomers are isomers, which are molecules with the same atoms bonded together in a different arrangement.<\/p>\n\n\n\n<p><\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p>Enantiomers are related to each other like left and right hands. They are non-superimposable, which means that they cannot be superimposed or overlaid onto each other. One enantiomer will fit snugly into the shape of the other&#8217;s mirror image, but they are not identical.<\/p>\n\n\n\n<p>Racemic molecules can occur naturally or they can be synthesized in the lab. They are often used in the production of drugs, as they can sometimes have different pharmacological effects depending on which enantiomer is present.<\/p>\n\n\n\n<p>In some cases, a racemic mixture may be separated into its individual enantiomers in order to study their effects separately. This process is known as resolution.<\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns1563_11684b-2e{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns1563_11684b-2e .kt-button{font-weight:normal;font-style:normal;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns1563_11684b-2e\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn1563_75778c-64.kb-button{width:initial;}.wp-block-kadence-advancedbtn .kb-btn1563_75778c-64.kb-button{color:#555555;border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}.wp-block-kadence-advancedbtn .kb-btn1563_75778c-64.kb-button:hover{color:#ffffff;background:#444444;border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}@media all and (max-width: 1024px){.wp-block-kadence-advancedbtn .kb-btn1563_75778c-64.kb-button{border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}}@media all and (max-width: 1024px){.wp-block-kadence-advancedbtn .kb-btn1563_75778c-64.kb-button:hover{border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}}@media all and (max-width: 1024px){.kb-btn1563_75778c-64.kb-button .kb-svg-icon-wrap{display:block;}}@media all and (max-width: 767px){.wp-block-kadence-advancedbtn .kb-btn1563_75778c-64.kb-button{border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}.wp-block-kadence-advancedbtn .kb-btn1563_75778c-64.kb-button:hover{border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}}<\/style><a class=\"kb-button kt-button button kb-btn1563_75778c-64 kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-outline kt-btn-has-text-true kt-btn-has-svg-false wp-block-kadence-singlebtn\" href=\"https:\/\/calliope.health\/contact\/\"><span class=\"kt-btn-inner-text\"><strong>START YOUR HEALING JOURNEY<\/strong><\/span><\/a><\/div>\n\n\n<style>.kb-row-layout-id1563_992b9b-34 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id1563_992b9b-34 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id1563_992b9b-34 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 2fr) minmax(0, 1fr);}.kb-row-layout-id1563_992b9b-34 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id1563_992b9b-34 > .kt-row-column-wrap{grid-template-columns:repeat(2, minmax(0, 1fr));}}@media all and (max-width: 767px){.kb-row-layout-id1563_992b9b-34 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id1563_992b9b-34 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-left-golden kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column1563_de4e00-0f > .kt-inside-inner-col,.kadence-column1563_de4e00-0f > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1563_de4e00-0f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1563_de4e00-0f > .kt-inside-inner-col{flex-direction:column;}.kadence-column1563_de4e00-0f > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1563_de4e00-0f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1563_de4e00-0f{position:relative;}@media all and (max-width: 1024px){.kadence-column1563_de4e00-0f > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column1563_de4e00-0f > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1563_de4e00-0f inner-column-1\"><div class=\"kt-inside-inner-col\">\n<p><strong>Why is esketamine\/Spravato rarely used in psychiatry practice?<\/strong><\/p>\n\n\n\n<p>There are two main reasons why clinicians tend to prefer racemic ketamine over esketamine. One is cost: Esketamine\/Spravato is ridiculously expensive. ($850 versus $2 for the generic medication). Second is lack of flexibility:The pharmaceutical company controls the route, the dose, and the frequency of esketamine treatment. This takes away the provider&#8217;s ability to utilize their clinical judgment, or to customize the treatment for the individual patient&#8217;s needs.&nbsp;<\/p>\n\n\n\n<p>Finally, Spravato is sub-psychedelic by design. In other words, Spravato is not fully dissociative, and would not be useful to achieve the levels of non-ordinary states of consciousness (the \u201cwindow of plasticity\u201d) that we believe to be highly useful in ketamine assisted psychotherapy (KAP).<\/p>\n\n\n\n<p>&nbsp;<\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column1563_3bac21-00 > .kt-inside-inner-col,.kadence-column1563_3bac21-00 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column1563_3bac21-00 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column1563_3bac21-00 > .kt-inside-inner-col{flex-direction:column;}.kadence-column1563_3bac21-00 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column1563_3bac21-00 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column1563_3bac21-00{position:relative;}@media all and (max-width: 1024px){.kadence-column1563_3bac21-00 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column1563_3bac21-00 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column1563_3bac21-00 inner-column-2\"><div class=\"kt-inside-inner-col\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_228931394-1024x683.jpeg\" alt=\"Esketamine (Spravato) vs. Ketamine\" class=\"wp-image-1567\" srcset=\"https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_228931394-1024x683.jpeg 1024w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_228931394-300x200.jpeg 300w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_228931394-768x512.jpeg 768w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_228931394-1536x1024.jpeg 1536w, https:\/\/calliope.health\/wp-content\/uploads\/2023\/01\/AdobeStock_228931394-2048x1365.jpeg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Spravato is sometimes chosen when the patient needs to use their medical insurance to pay for treatment. The lack of FDA coverage for generic ketamine for depression continues to be a problem.<\/figcaption><\/figure>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p><strong>Where to learn more about ketamine vs. esketamine<\/strong><\/p>\n\n\n\n<p>&nbsp;If you\u2019d like to learn more about ketamine vs. esketamine, take a look at this research article from the NIMH team, which compared the clinical efficacy of racemic ketamine and esketamine treatment:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33022440\/\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Intravenous ketamine appears to be more efficacious than intranasal esketamine for the treatment of depression<\/em>. <\/a><\/p>\n\n\n\n<p>Special thanks to Raquel Bennett, Psy.D. of the KRIYA Institute for citations and consulting for this article.&nbsp;<\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns1563_20e952-00{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns1563_20e952-00 .kt-button{font-weight:normal;font-style:normal;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns1563_20e952-00\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn1563_454c22-a8.kb-button{width:initial;}.wp-block-kadence-advancedbtn .kb-btn1563_454c22-a8.kb-button{color:#555555;border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}.wp-block-kadence-advancedbtn .kb-btn1563_454c22-a8.kb-button:hover{color:#ffffff;background:#444444;border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}@media all and (max-width: 1024px){.wp-block-kadence-advancedbtn .kb-btn1563_454c22-a8.kb-button{border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}}@media all and (max-width: 1024px){.wp-block-kadence-advancedbtn .kb-btn1563_454c22-a8.kb-button:hover{border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}}@media all and (max-width: 1024px){.kb-btn1563_454c22-a8.kb-button .kb-svg-icon-wrap{display:block;}}@media all and (max-width: 767px){.wp-block-kadence-advancedbtn .kb-btn1563_454c22-a8.kb-button{border-top-color:#555555;border-top-style:solid;border-right-color:#555555;border-right-style:solid;border-bottom-color:#555555;border-bottom-style:solid;border-left-color:#555555;border-left-style:solid;}.wp-block-kadence-advancedbtn .kb-btn1563_454c22-a8.kb-button:hover{border-top-color:#444444;border-top-style:solid;border-right-color:#444444;border-right-style:solid;border-bottom-color:#444444;border-bottom-style:solid;border-left-color:#444444;border-left-style:solid;}}<\/style><a class=\"kb-button kt-button button kb-btn1563_454c22-a8 kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-outline kt-btn-has-text-true kt-btn-has-svg-false wp-block-kadence-singlebtn\" href=\"https:\/\/calliope.health\/contact\/\"><span class=\"kt-btn-inner-text\"><strong>START YOUR HEALING JOURNEY<\/strong><\/span><\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ketamine and esketamine\/Spravato are both medications that belong to a class of drugs called dissociative anesthetics. They are both used for similar purposes, such as sedation, pain management, as an anesthetic, and in psychiatry to treat depression and its related behavioral complications. However, there are some differences between the two drugs. Ketamine is the more&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Esketamine (Spravato) vs. Ketamine: What you Need to Know<\/title>\n<meta name=\"description\" content=\"Explore the contrasts between Esketamine (Spravato) vs. Ketamine and make informed decisions about their applications.\" 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